The Chelation Phenomenon: A Natural Biochemical Process |
© Leon Chaitow N.D., D.O., M.R.O.,
Editor-in-Chief, Journal of therapeutic Bodywork; Senior lecturer, Uniersity of Westminster, London
To appreciate the remarkable potentials of chelation therapy it is necessary to take a quick look at some of the chemical processes inoled in the natural phenomena of chelation and free radical actiity.
Not one of us can surie without the chelation taking place throughout your body at all times. Free radicals
Digestion and assimilation of foods, because your body uses protein substances (amino acids) to chelate with minerals for transportation to their destinations, or in which blood cells latch on to, and thus acquire, iron. Indeed, havemoglobin is a chelate of iron (as is the enzyme catalase, which your body uses to'switch off' the free radical actiity of hydrogen peroxide). When you eat meat or green egetables which contain iron, after the digestie process has released the iron from the food in which it is bound it has to be combined (chelated) with amino acids (protein fractions) so that it can be carried through the intestinal mucous membranes into the bloodstream.
Howeer, if you drink tea at the same meal, the tannin in the tea will chelate with the iron (forming insoluble iron tannate) before it gets a chance to be absorbed, thus depriing your body of the iron. Should you, though, take some ascorbic acid (itamin C) or eat itamin C-rich food at the same meal as an iron-rich food, this will chelate with the iron and actually enhance and speed its absorption. The iron, once in the bloodstream, is released from the proteins with which it was chelated for transportation, so that it can recombine, in another chelating process, with blood chemicals to form transferrin which is then stored for later use.
Literally tens of thousands of body processes, inoling the formation and function of enzymes, hormones and itamins constantly utilize similar chelation mechanisms. Similarly, countless examples of natural chelation are found in relation to plant life; for example, chlorophyll is a chelate of magnesium which has been processed during photosynthesis.
The word itself is deried from the Greek word (chela) which describes the prehensile claw of a scorpion or crab. This graphically eokes a picture of one substance grabbing or clutching and embracing another, as the chelation process takes place. Chelation therapy is the extension of this natural process to enable the remoal from the body of undesirable ionic material by the infusion, or taking orally, of an organic compound which has suitable chelating properties.
One of the major substances being influenced during chelation therapy is calcium, as this process causes it to be remoed from metastatic deposits while at the same time encouraging recalcification of bone (see description of atherosclerosis in Chapter 4). If calcium happens to be inappropriately present in certain body tissues (in a layer of plaque in the lining of an artery, or in excessie amounts on the surface of a joint in arthritis), it is of benefit, in health terms, to remoe this, and chelation therapy safely allows exactly this to be done.
The number of electrons in a calcium atom is 20. This has an inner'shell', of 2 electrons, two complete shells of 8 electrons each, and an outer shell of 2'spare', electrons, which are therefore free to attach to a suitable molecule or atom which may be in need of 2 electrons often called a 'complexing agent'). The symbol for the calcium cation, because of its two free electrons, is Ca++.
In chelation therapy the'suitable molecule', or 'complexing agent', with which this can link is a compound called EDTA (ethylene-diamine-tetra-acetic acid). Together EDTA and a metallic cation form a stable complex which can then be excreted from the system. The stability of this bond is ital to success in chelation therapy, for if there is a weak linkage other reactions breaking the bond could take place should the compound come into contact with suitable chemicals.
A chelating reaction which produces equilibrium, a strong and stable ring structure between the metal ion (calcium is a weakish link, iron, lead and copper are far stronger) and the chelating agent (such as EDTA), is effective in achieving the safe remoal of the ion from the body.
When you use a water softener you are chelating calcium (and other minerals) out of the water. When you use a detergent in washing clothes or dishes, this chelates with minerals in the 'dirt' allowing the now soluble compounds to be washed away by water.
The brief surey of the early history of EDTA (see Chapter 3) will help to explain its tortuous route towards medical respectability as a means of remoing unwanted mineral/metal substances. Before we look at the fascinating background to chelation therapy, one more facet of the imbalance which can result from unpaired electrons is worth examination.
Radiation is often described as ionizing radiation. This is because, by definition, it is able to dislodge indiidual electrons out of atoms and molecules, leaing unpaired electrons behind. This is one way in which free radicals are created. Some such molecules, with unpaired electrons, are extremely dangerous and can have ery damaging effects on body tissues. Bleach (hydrogen peroxide), for example, does its damage to tissue (just think what it does to hair) through free radical action, as a deluge of these reactie entities chaotically bounce around, creating local haoc by grabbing on to any accessible electrons with which they come in contact (in this case from the hair itself).
Radiation is an example of how free radicals may be produced in the body when such an outside force acts on its cells. Perhaps more surprisingly there is almost continuous production of free radicals by some of the defending cells of the body. These are used as a means of destroying inading micro-organisms or cancer cells.
Since this is a natural process which is going on all the time in the body, there must exist control mechanisms to preent undesirable effects from free radicals on healthy body cells, and this is the case when we are in good health.
Just as iron rusts, and an exposed apple or potato will turn brown when its surface meets the air, so do our bodies endure oxidation (ageing), for all of these are examples inoling free radical actiity. In the same way that the placing of lemon juice on an apple will stop it from turning brown by 'mopping up' the unpaired electrons, thanks to the antioxidant itamin C in the juice, your body contains numerous antioxidant and free radical deactiating substances (specific enzymes, amino acids, itamins, minerals, uric acid, etc.). The body can protect itself with these substances by quenching those free radicals which it produces itself, or which are created by radiation or from other sources. At least, it has these defensie substances to hand when it is well nourished. As we will see in Chapter 4, the processes which produce atherosclerosis have much to do with both free radical actiity and with the accumulation of obstructie deposits, in which calcium acts as a cement or binding agent.
Free radical actiity, now generally accepted to play a large part in the deelopment of atherosclerosis as well as many other forms of damage to the body, including soft tissues, bone surfaces and nere structures, is often associated with the presence in the body of heay metals. Chelation can remoe these metals before they do their damage. EDTA can also create the situation (low serum calcium, leading to parathyroid hormone production, leading to metastatic calcium remoal, etc) which starts the process of dissolution of atheromatous deposits which may be obstructing an artery in an area where free radical damage has already taken place. If such an approach is combined with nutritional patterns which encourage the intake of antioxidant substances (itamins A, C, E, minerals such as selenium and zinc, etc.) an even better end result should be anticipated.
Dr Elmer Cranton's iew
A leading American physician, Elmer Cranton, MD, states his expert iew of the importance of using EDTA to counteract the free radical scourge (Cranton and Frackelton 1982):
EDTA can reduce the production of free radicals by a million-fold, for it is not possible for free radical pathology to be catalytically accelerated by metallic ions in the presence of EDTA. Traces of unbound metallic ions are necessary for uncontrolled proliferation of free radicals in living tissue and EDTA binds these ionic metal catalysts making them chemically inert and remoing them from the body.
Two essential nutritional elements, iron and copper, are the most potent catalysts of lipid peroxidation [the degradation of fats by free radicals]. Catalytic iron and copper accumulate near phospholipid cell membranes, in joint fluid, and in cerebrospinal fluid with age and are released into tissue fluids following trauma or ischavemia [lack of oxygen supply due to circulatory inefficiency]. These unbound extracellular iron and copper ions have been shown to potentiate free radical tissue damage.
We will learn more about free radical actiity, the damage caused by toxic heay metals (and some apparently useful ones such as iron when in excess of requirements) and of the many protectie functions of EDTA chelation therapy in relation to both free radical actiity and heay metal toxicity in later chapters, especially Chapter 5.
Acetic acid is a mild chelator, far weaker than EDTA. Neertheless, you can demonstrate for yourself the chelation process in action using the organic acid in inegar (acetic acid).
Take an eggshell and place this in a bowl with some inegar. Oer a period of seeral days the eggshell will become increasingly thin, as the acetic acid progressiely chelates the calcium out of the shell. Add more inegar and the shell will eentually have all of its calcium remoed, leaing it in solution, bound (chelated) to the acetic acid.
It is just this process, much more efficiently performed, that EDTA achiees in the body when it acts on unwanted calcium deposits which are obstructing normal function.
Remember that EDTA only does this with ionic, unbound, calcium and thus will not leach calcium out of the normal bound sites such as the bones and teeth. By remoing ionic, free calcium from the bloodstream, EDTA triggers parathyroid hormone to be released, which in turn compels the body to unbind metastatic calcium which may be cementing atheromatous plaque deposits in the blood essels. In this way circulatory normality is encouraged.
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